がん治療の選択肢を探されている方へ
がん治療では、がんの種類やステージだけでなく、これまでの治療内容、現在の体力、転移の有無、検査結果などによって、検討できる治療方針が異なります。
TGC東京がんクリニックでは、現在の治療に不安を感じている方や、再発・転移後の新たな治療の選択肢を探されている方からのご相談を受け付けています。患者様ご本人だけでなく、ご家族、ご親族、ご友人など、患者様を支える方からもお問い合わせいただけます。
患者様一人ひとりの病状や治療経過を確認し、光免疫療法をはじめとする治療方法の中から、検討できる選択肢を医師が判断し、ご提案いたします。
ステージや治療状況にかかわらず、まずはご相談ください
手術前後の方、抗がん剤治療中の方、再発や転移が心配な方、ステージ4・末期がんと診断された方など、治療状況に応じたご相談をお受けしています。
「治療が難しい」と言われた場合でも、すぐに治療を決めるのではなく、現在の状態を確認しながら、光免疫療法や他の治療との併用可否を検討します。
三好憲雄先生が著者または共著者として携わった原著論文の一部をご紹介します。
論文
原著論文（英文）
94件
1978–1989年32件
- Production and reaction of singlet oxygen in aqueous micellar solutions using pyrene as photosensitizer.
- Effects of indole and tryptophan on furan oxidation by singlet oxygen in micellar solutions.
- Quenching of singlet oxygen by sodium azide in reversed micellar solutions.
- Fluorescein-photosensitized furan oxidation in methanolic and reversed micellar solutions, Part I: Effects of amines.
- Fluorescein-photosensitized furan oxidation in methanolic and reversed micellar solutions, Part II: Kinetic analysis.
- Singlet oxygen production photosensitized by fluorescein in reversed micellar solutions.
- Buffer action of reversed micelles.
- Solubilization of methylene blue in reversed micelles, effect of water.
- Solubilization and photoreaction of thiazine dyes in reversed micelles.
- Generation of tris(4-dimethylaminophenyl)methanol (crystal violet carbinol) in reversed micelles.
- Fluorescence and photooxidation of 1-anilinonaphthalene-8-sulfonic acid in reversed micellar solutions and the effect of CCl4.
- Lifetime of singlet oxygen and quenching by NaN3 in mixed solvents.
- Photoradiation therapy of bladder tumors.
- Cellular uptake of hematoporphyrin derivative in KK-47 bladder cells.
- The similarity between the fluorescence spectra of hematoporphyrin derivative incorporated by rat bladder cancer tissue and trimethyl ammonium bromide micelles.
- Cellular binding of hematoporphyrin derivative in human bladder cancer cell line: KK-47.
- Whole bladder wall photoradiation therapy for carcinoma in situ of the bladder: A preliminary report.
- Hormone-dependent change of blood vessels in DMBA-induced rat mammary carcinoma and its regression studied by 3H-thymidine autoradiography.
- Computer analysis of subparameters of depolymerization rate constants in Feulgen DNA hydrolysis.
- Photodynamic inactivation of cultured human bladder cancer cells (KK-47) and argon-dye laser light.
- Flavin mononucleotide-sensitized photooxidation of indole acetic acid.
- Quantitative detection of DNA damages in the cerebellum and cerebrum by the analysis of Feulgen hydrolysis curve.
- Different instability of nuclear DNA to acid hydrolysis in cancerous and non-cancerous cells as revealed by fluorescence staining with acridine orange (AO).
- Ground and excited states of hematoporphyrin derivatives.
- The effect of hyperthermia on murine leukemia cells in combination with photodynamic therapy.
- Fluorescence lifetime of acridine orange in sodium dodecyl sulfate premicellar solution.
- Temperature-dependence of hematoporphyrin derivative uptake in vitro.
- Spectroscopic study of hematoporphyrin oligomer in tumor tissue.
- Spectroscopic property of hematoporphyrin oligomer product irradiated in micellar solution.
- Combination effect of hyperthermia and photodynamic therapy on carcinoma.
- Lectin histochemistry in rat-thyroid tumors.
- Multi-organ damage (MOD) induced by cancer cachexia and its pathogenesis.
1990–1999年19件
- Analysis of GFA-protein mRNA expression in developing bovine by in situ hybridization and northern blot hybridization.
- A new method of determining intracellular free Ca2+ concentration using quin-2 fluorescence.
- Proliferation and differentiation of thyroid-cell proliferation and differentiation of cancerous and non-cancerous thyroid tissues of rats.
- Integral laser photodynamic treatment of refractory multifocal bladder tumors.
- A new approach to the radical histochemistry.
- A novel class of nuclear RNA (aRNA) with long life span as a gene repressor candidate.
- Hyperthermic intravesical peplomycin perfusion treatment for bladder cancer.
- Differential immunohistochemical staining of cancer cells with anti-single-stranded DNA antiserum in ordinary pathological paraffin section by acid hydrolysis.
- Microfluorocytometric detection of nuclear DNA damage to cancer cells in squamous cell carcinoma after hyperthermia.
- Oxygen-independent photocleavage of DNA, and uptake of chlorophyll derivatives by cellular nuclei and mitochondria.
- Effect of gallium-porphyrin analogue ATX-70 on nitroxide formation from a cyclic secondary amine by ultrasound: On the mechanism of sonodynamic activation.
- EPR spin-trapping study of the sonolysis of H2O/D2O mixtures: Probing the temperatures of cavitation regions.
- EPR spin-trapping study of the decomposition of azo compounds in aqueous solutions by ultrasound: Potential for use as sonodynamic sensitizers for cell killing.
- Sonodynamic toxicity of gallium-porphyrin analogue ATX-70 in human leukemia cells.
- Photobleaching of fluorescent probe in microfluorometry and detection of active oxygen species.
- Production of radicals and acute apoptotic changes of palisade cells in early steps of Saintpaulia leaf spot appearance.
- Intracellular distribution of 5-aminolevulinic acid (5-ALA) produced protoporphyrin-IX (Pp-IX) in a cultivated cell and the 5-ALA-based photodynamic therapy (PDT) of squamous cell carcinoma (SCC).
- Cataract formation through the polyol pathway is associated with free radical production.
- Effects of cysteamine and cystamine on the sonochemical accumulation of hydrogen peroxide: Implications for their mechanisms of action in ultrasound-exposed cells.
2000–2009年43件
- Evidence against singlet oxygen formation by sonolysis of aqueous oxygen-saturated solutions of hematoporphyrin and rose bengal: The mechanism of sonodynamic therapy.
- Comparison of nitric oxide (NO) production in the tissue following hemorrhagic invasion and endotoxin administration in rats in relation to the pathogenesis of traumatic DIC.
- An FTIR bioimaging of biological material (Part 1: Bone).
- A preliminary study of the optical diagnosis of sclerosing osteomyelitis of the mandible by a simple operation using FT-IR microscopy.
- A new self-fabrication of large-scale deoxyribonucleic acid network on mica surfaces.
- Base sequence dependence of DNA studied by scanning tunneling microscopy.
- Combination effect of photodynamic and sonodynamic therapy on experimental skin squamous cell carcinoma in C3H/HeN mice.
- Photodynamic therapy based on combined use of 5-aminolevulinic acid with a pheophorbide-a derivative for murine tumors.
- Microscopic image resolved by fluorescence lifetime of a fluorescent probe incorporated in cultivated cancer cells.
- New methods for preparing FT-IR microscopic samples of undecalcified hard tissues.
- Effects of pH and surfactant on the ultrasound-induced chemiluminescence of luminol.
- Monomerization of photosensitizers by ultrasound irradiation in surfactant micellar solutions.
- Formation and control of two-dimensional deoxyribonucleic acid network.
- Herniation of cervical intervertebral disc.
- Observation of molecular changes of a necrotic tissue from a murine carcinoma by Fourier-transform infrared microspectroscopy.
- FTIR spectra of calcified aorta tissue.
- Singlet oxygen trapping by DRD156 in micellar solutions.
- Irradiation effects of IR-FEL on tumor tissues.
- Correlation between sonochemistry of surfactant solutions and human leukemia cell killing by ultrasound and porphyrins.
- Irrigational therapy of a dentigerous cyst in a geriatric patient: A case report.
- X-ray microscopy in Ritsumeikan synchrotron radiation center.
- Fluorescent analysis of 5-aminolevulinic acid-induced protoporphyrin-IX in mouse transplanted tumor tissues.
- Hydroxyapatite maturity in the calcified cartilage and underlying subchondral bone of guinea pigs with spontaneous osteoarthritis: Analysis by Fourier transform infrared microspectroscopy.
- In light of recent developments, application of fluorescence spectral analysis in tumor diagnosis.
- Imaging of the atheroma in a frozen-section of human atherosclerotic tissue by FT-IR microscopy.
- Correlation between acoustic cavitation noise and yield enhancement of sonochemical reaction by particle addition.
- n-Alkyl glucopyranosides completely inhibit ultrasound-induced cytolysis.
- Enhancement of sonochemical reaction by particle addition.
- Correlation between sonochemistry of surfactant solutions and human leukaemia cell killing by ultrasound and porphyrins.
- Influence of administration methods on the accumulation of ALA-induced Pp-IX in mouse tongue tumors.
- Reinforcement therapy using nitric oxide synthase inhibitors against endotoxin shock in dogs.
- PD and PDT with porphyrin precursors in Japan.
- Massive apoptotic cell death of human glioma cells via a mitochondrial following 5-aminolevulinic acid-mediated photodynamic therapy.
- Terahertz imaging diagnostics of cancer tissues with a chemometrics technique.
- FTIR imaging of TiO2/Pp-IX particles in transplanted SCC tissue.
- Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: Pathological study.
- Phosphate mapping of sialoliths with Raman microspectroscopy.
- Ultrasound-induced cytolysis of cancer cells is enhanced in the presence of micron-sized alumina particles.
- Functional mapping of caries enamel of human teeth with Raman microspectroscopy.
- Characterization of chitosan/citrate and chitosan/acetate films and applications for wound healing.
- Dynamic adsorption properties of n-alkyl glucopyranosides determine their ability to inhibit cytolysis mediated by acoustic cavitation.
- Terahertz pulsed imaging of frozen biological tissues.
- Enhancement of 5-aminolevulinic acid-induced oxidative stress on two cancer cell lines by gold nanoparticles.
原著論文（和文）
19件
1985–1994年17件
- PhotoradiationとHyperthermiaの併用効果に関する基礎的研究
- Photodynamic Therapy（PDT）併用時におけるHyperthermiaの効果
- PhotoradiationとHyperthermiaの併用効果に関する基礎的研究（第2報）
- BBN誘発ラット膀胱腫瘍におけるヘマトポルフィリン誘導体の組織内局在とアルゴン・色素レーザー光照射併用による光力学的腫瘍効果の検討
- ヘマトポルフィリン誘導体（HpD）とマイクロ波照射によるL1210とCML培養細胞の殺細胞効果
- アルゴンイオンレーザー光照射によるヘマトポルフィリン誘導体（HpD）オリゴマーの光化学反応生成物の分光特性
- Scattering Mediumを用いたWhole Bladder Wall Photodynamic Therapyの実験的研究
- 細胞内取り込みアドリアマイシンの光増感による殺細胞作用の実験的研究
- ヒト膀胱癌由来培養細胞（KK-47）によるアドリアマイシン（ADR）とヘマトポルフィリン誘導体（HpD）の取込みおよびその殺細胞効果
- 男子不妊症患者における加水分解曲線解析法を用いた静止DNAの検討（第1報）
- 皮膚悪性腫瘍に対するX線照射のヘマトポルフィリン・オリゴマーおよびカフェインによる増感効果に関する研究
- ラット甲状腺腫瘍におけるレクチン組織化学
- 各種光増感剤の蛍光特性についての検討
- 男子不妊症患者における加水分解曲線解析法を用いた静止DNAの検討―第2報：妊よう力評価の試み―
- 細胞核DNA定量に使用する蛍光色素の蛍光顕微分光法による分光学的検討
- 光増感剤とうよごレーザーを照射した実験皮膚癌の電子顕微鏡的検討
- ヒト悪性黒色腫由来培養細胞浮遊液系での光増感剤反応による活性酸素の動態
2005–2006年2件
- Photodynamic therapy（PDT）特集【総説】―1．PDTの基礎―PDTメカニズムと体内光生成物の反応性について―
- Review Article：赤外線自由電子レーザーの医学応用とその基礎的研究―腎臓結石成分に吸収のある赤外FEL光照射によるFT-IRスペクトル変化―
光免疫療法を含めた治療方針を検討します
光免疫療法は、薬剤と光照射を組み合わせて行う治療法の一つです。
ただし、すべての患者様に適しているわけではありません。
当院では、光免疫療法だけを前提にするのではなく、患者様の病状、治療歴、体力、現在受けている治療内容を確認したうえで、必要に応じてNK細胞療法などの併用も含めて検討します。
リスクと副作用等詳細はこちら
| リスクと副作用 |
光免疫療法による治療は侵襲性の少ない治療法です。
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|---|---|
| 未承認医薬品等であることの明示 |
本治療で使用する未承認医薬品等は、医薬品医療機器等法上の承認を現在得ていないものです。 日本では、未承認医薬品等を医師の責任において使用することが可能です。 |
| 入手経路の明示 | 現在、国内販売代理店経由で入手しております。 |
| 国内の承認医薬品等の有無の明示 | 本治療に用いるものと同一の性能を有する他の国内承認医薬品は現在ありません。 |
| 諸外国における安全性等に係る情報の明示 | 諸外国における安全性等に係る情報は現在ありません。 |
